semaglutide(Ozempic (SC, T2DM), Wegovy (SC, weight management), Rybelsus (oral T2DM))
GLP-1 receptor agonist (long-acting)
Pronunciation
/ˌsɛməˈɡluːtaɪd/
International Phonetic Alphabet (IPA). Say it aloud once — you will remember it forever.
At a glance
- Generic name
- semaglutide
- Brand names
- Ozempic (SC, T2DM), Wegovy (SC, weight management), Rybelsus (oral T2DM)
- Therapeutic class
- GLP-1 receptor agonist (long-acting)
- Mechanism (summary)
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Clinical pearls
- Inject SC weekly (Ozempic/Wegovy); rotate abdomen/thigh/upper arm.
- Rybelsus: take on empty stomach with up to 4 oz water; wait 30 min before food/other meds.
- Nausea is most common - start low, go slow with food.
- Report severe abdominal pain, persistent vomiting, lump/swelling in neck.
- Storage: refrigerate pens before first use; in-use pen room temp per label.
Related drugs in this class
Sources
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