metoprolol succinate(Toprol-XL)
Cardioselective (β1-selective) beta-blocker, extended-release
Pronunciation
/məˈtoʊproʊlɒl ˈsʌksɪneɪt/ Mechanism of action Selectively blocks β1-adrenergic receptors in the heart, reducing heart rate, contractility, and AV nodal conduction. Lowers myocardial oxygen demand. In heart failure with reduced ejection fraction (HFrEF), chronic β1 blockade reverses sympathetic-mediated cardiac remodeling and improves survival. Selectivity diminishes at higher doses \\[1\\]. Standard dosing -/
International Phonetic Alphabet (IPA). Say it aloud once — you will remember it forever.
At a glance
- Generic name
- metoprolol succinate
- Brand names
- Toprol-XL
- Therapeutic class
- Cardioselective (β1-selective) beta-blocker, extended-release
- Mechanism (summary)
- Selectively blocks β1-adrenergic receptors in the heart, reducing heart rate, contractility, and AV nodal conduction. Lowers myocardial oxygen demand. In heart failure with reduced ejection fraction (HFrEF), chronic β1 blockade reverses sympathetic-mediated cardiac remodeling ...
Clinical pearls
- Take at the same time each day, with or just after food, to keep
- absorption consistent.
- Swallow the tablet whole, or split along the score line if your
- prescriber says so --- do not crush or chew.
- Do not stop suddenly. Stopping abruptly can cause chest pain, rapid
Sources
See how metoprolol succinate appears in NAPLEX-style questions
PharmDHub Premium includes a full drug card, dosing, boxed warnings, drug-drug interactions, and practice questions built around this drug.